Document 2361
 DOCN  M94A2361
 TI    Mortality in HIV infection in Switzerland and U.S.A. Swiss HIV Cohort
       Study (SHCS) and Community Programs for Clinical Research on AIDS
       (CPCRA).
 DT    9412
 AU    Egger M; Wentworth D; von Overbeck J; Sherer R; Ledergerber B;
       Saravolatz L
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):321 (abstract no. PC0215). Unique
       Identifier : AIDSLINE ICA10/94370214
 AB    OBJECTIVE: To compare mortality of patients with HIV infection enrolled
       in cohort studies in Switzerland and the US. Patients and setting: The
       SHCS and the CPCRA are cohort studies of adult HIV-infected patients
       with 6 and 17 recruiting centers respectively. Both studies used similar
       standardised methods for data collection and follow-up. METHODS:
       Analyses are restricted to patients with a baseline CD4+ cell count
       within 90 days of enrollment. Cumulative mortality is estimated using
       the Kaplan-Meier method. RESULTS: 4,965 Swiss and 4,547 US patients
       enrolled between 1/88 and 7/93 and 9/90 and 9/93 respectively were
       considered. Compared to US participants, Swiss participants were younger
       (33 vs. 38 years), more likely to be female (27% vs. 17%) and injecting
       drug users (44% vs. 30%). Median CD4+ cell counts at entry were 324 and
       150. Nearly all Swiss participants were white, whereas 52% of US
       participants were non-white. Kaplan-Meier lifetable estimates stratified
       by CD4+ cell counts were: TABULAR DATA, SEE ABSTRACT VOLUME.
       CONCLUSIONS: Despite important differences at baseline, the mortality of
       Swiss and US cohort participants overall appears to be similar when
       stratified on CD 4 cell counts at entry. Detailed comparisons across
       different cohorts may identify factors associated with disease
       progression and mortality.
 DE    Adult  Cohort Studies  Comparative Study  Female  Human  HIV
       Infections/IMMUNOLOGY/*MORTALITY  Leukocyte Count  Male
       Switzerland/EPIDEMIOLOGY  T4 Lymphocytes  United States/EPIDEMIOLOGY
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).